For more information regarding testosterone replacment and testosterone injections, you are welcome to fill out our quick info form or to contact an AAG Health hormone replacement specialist at 1-800-325-1325.
Importantly for men with very low t, low testosterone levels can be the principal cause of low sex drive, loss of desire, sexual performance problems like soft erections, ED or erectile dysfunction (impotence), loss of muscle mass and bone density, loss of energy, stamina and
strength, constant insomnia, feeling tired all the time, loss of ambiton and drive, shyness and withdrawal, extreme mood swings and irritability.
You may have been tested for low testosterone and are not happy with
your current doctor's recommendations regarding low testosterone treatment and have
decided to do some online testosterone research. If your physician has told you, "It's a normal part of male aging" or has suggested you "exercise more frequently, get "more rest or sleep", take some "vitamins" or prescribes male enhancement pills like Cialis or Viagara, but they aren't
working, you may need Testosterone Replacement Therapy - TRT.
Testosterone Replacement Therapy programs comprise physician-supervised prescription testosterone in the form of bio-identical testosterone injections, testosterone cream, patch or gel.
All the other testosterone formulations are self-limiting in how much testosterone can be absorbed. They may be enough to get you to the mid range of normal. For a lot of men, mid range testosterone levels aren't enough to increase energy, libido, muscle mass and mood to a satisfactory level. It is ideal to be in the high normal range to help alleviate the symptoms of low t. Testosterone injection dosages can also be titrated much easier compared to the other formulations. There are positive effects of Testosterone Therapy and you should always speak with your hormone replacement doctor to gain a good understanding of the benefits and side effects of testosterone therapy using testosterone cypionate injections or testosterone enanthate injections for men.
Testosterone cypionate injection, USP, for intramuscular injection,
contains Testosterone cypionate which is the oil-soluble 17
(beta)-cyclopentylpropionate ester of the androgenic hormone
Testosterone.
Testosterone cypionate is a white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane,
ether, and soluble in vegetable oils. The chemical name for Testosterone cypionate is
androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17?)-. Its
molecular formula is C27H40O3, and the molecular weight 412.61.
The structural formula is represented below:
Testosterone cypionate injection, USP is available in two strengths, 100 mg/mL and 200 mg/mL Testosterone cypionate.
Each mL of the 100 mg/mL solution contains:
| Testosterone cypionate |
100 mg |
| Benzyl benzoate |
0.1 mL |
| Cottonseed oil |
736 mg |
| Benzyl alcohol (as preservative) |
9.45 mg |
Each mL of the 200 mg/mL solution contains:
| Testosterone cypionate |
200 mg |
| Benzyl benzoate |
0.2 mL |
| Cottonseed oil |
560 mg |
| Benzyl alcohol (as preservative) |
9.45 mg |
Testosterone - Clinical Pharmacology
Endogenous androgens are responsible for normal growth and
development of the male sex organs and for maintenance of secondary sex
characteristics. These effects include growth and maturation of the
prostate, seminal vesicles, penis, and scrotum; development of male hair
distribution, such as beard, pubic, chest, and axillary hair; laryngeal
enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase
protein anabolism and decrease protein catabolism. Nitrogen balance is
improved only when there is sufficient intake of calories and protein.
Androgens are responsible for the growth spurt of adolescence and for
eventual termination of linear growth, brought about by fusion of the
epiphyseal growth centers. In children, exogenous androgens accelerate
linear growth rates, but may cause disproportionate advancement in bone
maturation. Use over long periods may result in fusion of the epiphyseal
growth centers and termination of the growth process. Androgens have
been reported to stimulate production of red blood cells by enhancing
production of erythropoietic stimulation factor.
During exogenous administration of androgens, endogenous Testosterone
release is inhibited through feedback inhibition of pituitary
luteinizing hormone (LH). At large doses of exogenous androgens,
spermatogenesis may also be suppressed through feedback inhibition of
pituitary follicle stimulating hormone (FSH).
There is a lack of substantial evidence that androgens are effective
in fractures, surgery, convalescence, and functional uterine bleeding.
Pharmacokinetics
Testosterone esters are less polar than free Testosterone.
Testosterone esters in oil injected intramuscularly are absorbed slowly
from the lipid phase; thus, Testosterone cypionate can be given at
intervals of two to four weeks.
Testosterone in plasma is 98 percent bound to a specific
Testosterone-estradiol binding globulin, and about 2 percent is free.
Generally, the amount of this sex-hormone binding globulin in the plasma
will determine the distribution of Testosterone between free and bound
forms, and the free Testosterone concentration will determine its
half-life.
About 90 percent of a dose of Testosterone is excreted in the urine
as glucuronic and sulfuric acid conjugates of Testosterone and its
metabolites; about 6 percent of a dose is excreted in the feces, mostly
in the conjugated form. Inactivation of Testosterone occurs primarily in
the liver. Testosterone is metabolized to various 17-keto steroids
through two different pathways.
The half-life of Testosterone cypionate when injected intramuscularly is approximately eight days.
In many tissues the activity of Testosterone appears to depend on
reduction to dihydroTestosterone, which binds to cytosol receptor
proteins. The steroid-receptor complex is transported to the nucleus
where it initiates transcription events and cellular changes related to
androgen action.
Indications and Usage for Testosterone
Testosterone cypionate injection, USP is indicated for replacement
therapy in the male in conditions associated with symptoms of deficiency
or absence of endogenous Testosterone.
- Primary hypogonadism (congenital or acquired) testicular failure due
to cryptorchidism, bilateral torsion, orchitis, vanishing testis
syndrome; or orchidectomy.
- Hypogonadotropic hypogonadism (congenital or acquired) idiopathic
gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from
tumors, trauma, or radiation.
Contraindications
- Known hypersensitivity to the drug
- Males with carcinoma of the breast
- Males with known or suspected carcinoma of the prostate gland
- Women who are or who may become pregnant
- Patients with serious cardiac, hepatic or renal disease
Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism if hormone treatment protocol is not strictly followed.
Testosterone has not been shown to be safe and effective for the
enhancement of athletic performance. Because of the potential risk of
serious adverse health effects, this drug should not be used for such
purpose.
Testosterone cypionate should not be used interchangeably with
Testosterone propionate because of differences in duration of action.
Testosterone cypionate is not for intravenous use.
Information for Patients
Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.
Laboratory Tests
Hemoglobin and hematocrit levels (to detect polycythemia) should be
checked periodically in patients receiving long-term androgen
administration. Serum cholesterol may increase during androgen therapy.
Drug Interactions
Androgens may increase sensitivity to oral anticoagulants. Dosage of
the anticoagulant may require reduction in order to maintain
satisfactory therapeutic hypoprothrombinemia. Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.
Testosterone Dosage and Administration
Testosterone cypionate injection, USP is for intramuscular use only.
Testosterone cypionate should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle.
Testosterone Cypionate Injection Dosages. The suggested dosage for Testosterone cypionate injection, USP varies
depending on the age, sex, and diagnosis of the individual patient.
Dosage is adjusted according to the patient’s response and the
appearance of adverse reactions.
Testosterone dosages for hypogonadism, andropause (male menopause). Various dosage regimens have been used to induce pubertal changes in
hypogonadal males; some experts have advocated lower dosages initially,
gradually increasing the dose as puberty progresses, with or without a
decrease to maintenance levels. Other experts emphasize that higher
dosages are needed to induce pubertal changes and lower dosages can be
used for maintenance after puberty. The chronological and skeletal ages
must be taken into consideration, both in determining the initial dose
and in adjusting the dose.
For testosterone replacement in the hypogonadal male, 50 to 400 mg should be administered every two to four weeks. Parenteral hormone drug products inlcuding testosterone for injection should be inspected visually for particulate
matter and discoloration prior to administration, whenever solution and
container permit. Warming and shaking the vial should redissolve any
crystals that may have formed during storage at temperatures lower than
recommended.
Other Topics for Testosterone
- Testosterone Cypionate Injection
- Testosterone Professional Patient Advice
- Testosterone Health & Medical Facts
- Testosterone Buccal (Gum) Information
- AndroGel Testosterone Gel Medical Facts
- Androderm Testosterone Patch Medical Facts
- Testopel Testosterone Pellets Medical Facts
- Axiron Testosterone Solution & Medical Facts
- Delatestryl Testosterone Solution Medical Facts
- Depo-Testosterone Injectable Testosterone Medical Facts
- Fortesta Testosterone Solution Medical Facts
- Striant Testosterone Solution Medical Facts
- Testim Gel for Testosterone Replacement Medical Facts
Testosterone Deficiencies
- Low T - Low Testosterone Levels
- Delayed Puberty, Male
- Hypogonadism, Male
- Androgen Deficiency
You will talk to your doctor physician about the advantages of the best
testosterone method and dose though injections to get you to the greater
quality of life and health you've been looking for. Best Practices for
Low Testosterone Treatment in Men When performed correctly, testosterone
treatment can have profound effects on mental, physical, sexual and
emotional health.
Testosterone Injection is a superior form of Treatment
for Low Testosterone - Low T.
Testosterone injections, IM (intramuscular) is the preferred type of method used for testosterone when treating hypogonadism. It is considered by many hormone replacement doctors that testosterone creams, gels or patches are less effective and these testosterone alternatives poorer absorption leading to less efficacy.
Who uses the testosterone creams, patches and gels? Men who don't like injections, will not inject themselves with self-adminitered testosterone programs or lack the time to go to their hormone physician's office for a testosterone injection. However, Testosterone Shots are more effective as a testosterone hormone delivery method.
All the other testosterone formulations are self-limiting in how much testosterone can be absorbed.
They may be enough to get you to the mid range of normal but for many androgen deficient men, mid range isn't enough to increase energy, libido, muscle mass or mood to a satisfactory level.
What many men will need is to be in the high normal range to alleviate low t symptoms.
Testosterone injection dosages can also be titrated much easier compared to the other formulations.
About Testosterone Pills
Testosterone pills (Andriol) are another new formulation to treat low testosterone levels in men. They have poor absorption rates, need to be taken with large amounts of dietary fats, and are quite expensive. Pills must go through the liver and are the least desirable testosterone delivery method from a men's health perspective. If the absorption rates were higher, Andriol would be probably the top running low T replacement formulation today. However, you are most likely only get to the mid range of normal for your testosterone blood tests using these methods.
Implantable Testosterone Pellets Implantable testosterone pellets and the testosterone patch Androderm and Testoderm can be prescribed. The testosterone patches sometimes have low absorption rates, may cause a rash over the application site and can be difficult to use.
About Testosterone Pellets and Patches
Testosterone pellets - implantable testosterone pellets and testosterone patch Androderm / Testoderm be prescribed. Pellets can be very effective and convenient for some men who don't want to think about a testosterone injection or cream/gel application schedule. Testosterone patches sometimes have low absorption, may cause a rash over the application site and can be difficult to use.
Best Instructions for Drawing and Injecting Testosterone
using Injectable Testosterone for Intramuscular Injection.
If testosterone administration is performed correctly including use of estrogen blockers and HCG to keep the testes stimulated, testosterone side effects are diminished and an increase in the quality of life are common. The following information is the culmination of today's best practices in hypogonadism treatment, developed by leading doctors in hormone replacement therapy. The T Treatment Trifecta is normally Testosterone + HCG + Arimidex
If your doctor only prescribes testosterone by itself, you may have unintended side effects. The problem with testosterone only hormone replacment regimens is that one of the main metabolites estrogen can become excessive. High estrogen levels negates the benefits of TRT, Testosterone Replacment. Extreme fatigue, impotence, weight gain, water retention (bloat), insomnia, depression, memory loss, moodiness and brain fog are all commonly associated with excessively high estrogen. The Estrogen Blocker Arimidex (Anastrazole) Lowers Estrogen Levels.
The optimal testosterone replacement solution is to add estrogen lowering medication Arimidex (anastrozole) or Aromasin (exemestane) to your hormone therapy protocol. Arimidex is a class of medication called aromatase inhibitor which blocks the conversion of testosterone to estrogen. It helps by forcing testosterone output to remain high while keeping estrogen levels low. Once your optimal testosterone and estrogen levels are established, your hormone physician will monitor you continued progress.
HCG is used to stimulate the testes to avoid shrinking or atrophy of the testicles that is often associated fertility problems. HCG Boosts Natural Androgen Levels. This is where the medication HCG (Human Chorionic Gonadotropin) comes in. It helps prevent both the infertility and testicle shrinkage problems that commonly occur during testosterone treatment. Basically, your testicles shrink because your body's under the misguided notion it doesn't need to make testosterone anymore.
When your androgens are being supplied from an external source, your testes tend to shut down their own production. HGC does more than maintain or increase testicle size, it stimulates your testes and increases adrenal function which has many positive effects on well-being, libido and energy. Learn more about HCG and male hormone therapy - HCG Therapy & HCG for Testosterone
.
Testosterone Treatment Dosages for Men - 50mg Testosterone enanthate/cypionate every third day.
- 0.25mg Arimidex every third day.
- 500IU HCG every third day.
Most hormone physicians ensure that Armidex (Anastrazole) and HCG is taken at the best time for each patient's hormone treatment protocol. Physicians may suggest that all medications be taken on the same day or at a differen time as prescribed. Many doctors want to prescribe dosages over longer periods of time, and testosterone's half life should be kept in mind to prevent fluctuations and the variable effects that go with it. The half life of a medication is the amount of time it takes to metabolize to half it's original dose. The Half Life of Testosterone, for example in both testosterone cypionate and enanthate - have a half life of approximately 7 days. A 100mg injection would then result in 50mg after 7 days, 25mg after 14 days, and so on and so on. If a patient waits too long after the dosing time the doctors suggests, mental, physical, and emotional symptoms could occur. For this reason, it is extremely important that dosing is properly scheduled and followed.
Some hormone physicians propose an every third day (E3D) dosing regimen, results in the most stable androgen levels over time. Once you've been on the testosterone, Arimidex, and HCG protocol for 6 weeks, it's usually a good idea to get your blood levels tested to see where you're at.
Testosterone Therapy & Andropause Symptoms
The symptoms of male menopause:
Uncontrolled Weight Gain
Flabbiness around the Mid-Section
Insomnia, Sleep Disturbance or Sleep Apnea
Memory Loss, Inabilty to Focus or Concentrate
Erectile Dysfunction (ED), Soft Erections or Impotence
Diminished Libido or Lack of Sexual Desire
Increased Hair Loss, Dry Skin and Nails
Hot Flashes or Profuse Sweating
Muscle Loss or Weakness
Bone Loss / Oseoporosis
Loss of Ambition or Drive
Depression or Sadness
Fatigue or Feeling Tired All The Time
Night Sweats or Chills
Gynecomastia (Male Breasts)
Irritablity, Bad Temper & Moodiness
AAG Health offers male hormone treatments with individualized, Physician-Prescribed Hormone Therapies including Bio-Identical Testosterone Injections for Male Hormone Therapy. You’ll gain access to Hormone Specialists who are Board Certified in Age Management Medicine, Bio-Identical Hormone Replacement (BHRT), Anti Aging Medicine, Weight Loss and Weight Management programs. AAG Health & Wellness serves male and female patients throughout the United States and worldwide with age-related and life extending therapies, such as Hormone Replacement, Hormone Modulation and Optimization, Testosterone Replacement, HGH Replacment, Injectable Human Growth Hormone, Healthy Aging and Weight Loss Programs, Anti-Aging Nutritional Supplements, Antiaging Vitamins and Natural Hormone Supplementation. These healthy aging and hormone optimization programs are designed to meet your health goals.
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Call AAG Health, the Testosterone Therapy Experts at 1-800-325-1325 to find out more information on Testosterone Pellets, Testosterone Implants, HGH Injectables, Testosterone Injectables, Testosterone Boosters and Supplements, Testosterone Creams, Testosterone Gels, Testosterone Patches for Testosterone Replacement.
